HCID 178505591, compound → HCID 178505595, compound

HRID 489943Notes

Reaction equation

HRID 489943 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[C:9]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)=[N:10][NH:11][CH:12]=2)[CH:5]=[CH:4][N:3]=1>C(N)C1C=CC=CC=1>[F:19][C:16]1[CH:17]=[CH:18][C:13]([C:9]2[C:8]([C:6]3[CH:5]=[CH:4][N:3]=[C:2]([NH:10][CH2:9][C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)[N:7]=3)=[CH:12][NH:11][N:10]=2)=[CH:14][CH:15]=1

Participants

3

Reactant 1

HCID 178505591HCID 178505591, compound

Product 1

HCID 178505595HCID 178505595, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 7504BenzylamineSolvent

Procedure

This compound was synthesize by refluxing 2-chloro-4-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]pyrimidine prepared in accordance with Example A-299 in benzylamine overnight. The product, 4-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]-N-(phenylmethyl)-2-pyrimidinamine, was obtained as a white solid in 95% yield; mp: 216-217° C.; Anal. Calc'd for C20H16FN5: C, 69.55; H, 4.67; N, 20.28. Found: C, 69.73; H, 4.69; N, 19.90.

Workup

  1. customThis compound was synthesize

Sources & evidence

ORD record
ord-e8610580900343a4ad4946dd26329e3b
Source dataset
uspto-grants-2005_12
Patent number
US06979686B1

Reaction notes

Loading…