Hydroxyamine hydrochloride → 5-(4-Chlorophenyl)-4-(pyridin-4-yl)isoxazole

HRID 489968Notes

Reaction equation

HRID 489968 reaction equation
C[N:2](C)[CH:3]=[C:4]([C:14]1[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=1)[C:5]([C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1)=[O:6].Cl.NO>C(O)C>[Cl:13][C:10]1[CH:11]=[CH:12][C:7]([C:5]2[O:6][N:2]=[CH:3][C:4]=2[C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 540776133-Dimethylamino-1-(4-chlorophenyl)-2-(pyridin-4-yl)-2-propen-1-one

Product 1

HCID 220374565-(4-Chlorophenyl)-4-(pyridin-4-yl)isoxazoleYield 100.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3-dimethylamino-1-(4-chlorophenyl)-2-(pyridin-4-yl)-2-propen-1-one (22.80 g, 79.7 mmol), hydroxylamine hydrochloride (18.01 g, 0.26 mole), and 150 mL ethanol was heated to reflux for 30 minutes. The reaction mixture was then cooled to room temperature and concentrated in vacuo. The residue was dissolved in 1N hydrochloric acid and then treated with an aqueous saturated solution of sodium bicarbonate. The precipitates were collected by filtration, washed with water and ethanol, and dried to yield 5-(4-chlorophenyl)-4-(pyridin-4-yl)isoxazole (20.50 g, 93%). m.p. 120.8-120.9° C. 1H NMR (CDCl3/CD3OD/300 MHz) δ 8.53 (d, 2H), 8.46 (s, 1H), 7.51 (d, 2H), 7.41-7.34 (m, 4H). ESLRMS m/z 257 (M+H). ESHRMS m/z 257.0457 (M+H, C14H2N2OCl requires 257.0482).

Workup

  1. temperatureto reflux for 30 minutes
  2. concentrationconcentrated in vacuo
  3. dissolutionThe residue was dissolved in 1N hydrochloric acid
  4. additiontreated with an aqueous saturated solution of sodium bicarbonate
  5. filtrationThe precipitates were collected by filtration
  6. washwashed with water and ethanol
  7. customdried

Sources & evidence

ORD record
ord-28a363713b1a44bb8b7d4e2c8951b2dd
Source dataset
uspto-grants-2005_12
Patent number
US06979686B1

Reaction notes

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