(S)-N-Benzyl-2-(Boc-amino)-2-phenylacetamide → (S)-2-Amino-N-benzyl-2-phenyl-acetamide hydrochloride

HRID 489992Notes

Reaction equation

HRID 489992 reaction equation
C(OC(=O)[NH:7][C@H:8]([C:15](=[O:24])[NH:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(C)(C)C.[ClH:26].O1CCOCC1>>[ClH:26].[NH2:7][C@@H:8]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:15]([NH:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:24]

Participants

3

Reactant 2

HCID 12148799(S)-N-Benzyl-2-(Boc-amino)-2-phenylacetamideHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 68955044(S)-2-Amino-N-benzyl-2-phenyl-acetamide hydrochloride

Procedure

(S)-(Benzylcarbamoyl-phenyl-methyl)-carbamic acid tert-butyl ester (0.85 g, 2.50 mmol) was dissolved in HCl/dioxane(10 mL, 4.0 M). The mixture was stirred at room temperature overnight. The volatiles were removed under reduced pressure to provide the desired product in quantitative yield.

Workup

  1. customThe volatiles were removed under reduced pressure

Sources & evidence

ORD record
ord-45243f1e84b54dee9a6a87609a732368
Source dataset
uspto-grants-2005_12
Patent number
US06979692B2

Reaction notes

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