Hydrochloric Acid → HCID 178502825, 화합물

HRID 490018노트

반응식

HRID 490018 반응식
[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:9])[NH2:8].[CH3:13][N:14]1[N:20]=[C:19]([OH:21])[C:17](=[O:18])[N:16]=[C:15]1[S:22][CH2:23][C:24]1[CH2:45][S:44][C@@H:27]2[C@H:28]([NH:31][C:32](/[C:34](/[C:38]3[N:42]=[C:41]([NH2:43])[S:40][CH:39]=3)=[N:35]\[O:36][CH3:37])=[O:33])[C:29](=[O:30])[N:26]2[C:25]=1[C:46]([OH:48])=[O:47].Cl>O>[CH3:13][N:14]1[N:20]=[C:19]([OH:21])[C:17](=[O:18])[N:16]=[C:15]1[S:22][CH2:23][C:24]1[CH2:45][S:44][C@@H:27]2[C@H:28]([NH:31][C:32](/[C:34](/[C:38]3[N:42]=[C:41]([NH2:43])[S:40][CH:39]=3)=[N:35]\[O:36][CH3:37])=[O:33])[C:29](=[O:30])[N:26]2[C:25]=1[C:46]([OH:48])=[O:47].[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:8])[NH2:9]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 178418600HCID 178418600, 화합물3회HCID 178502822HCID 178502822, 화합물2회

생성물 1

HCID 178502825HCID 178502825, 화합물

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

About 582 mg (3.34 mole) of arginine was dissolved in 50 ml of distilled water. Additionally, about 1.0 grams (1.67 mole) of ceftriaxone was dissolved in 50 ml of a separate volume of distilled water. The solution containing arginine was adjusted with 1N-HCl until the pH reached 6.0. The ceftriaxone solution was then added to the arginine solution and mixed by a magnetic stirrer at room temperature for 1 hour forming a ceftriaxone-arginine solution. To the ceftriaxone-arginine solution was added about 400 mg of carrageenan and the solution was mixed by magnetic stirrer at room temperature for 2 hours. A ceftriaxone-arginine-carrageenan complex was formed which was freeze-dried while in the swollen state, yielding about 1.84 g of the freeze dried complex.

후처리

  1. additionmixed by a magnetic stirrer at room temperature for 1 hour

출처 및 근거

ORD 기록
ord-19e12ca503e54b8096b410129fa742eb
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07527807B2

반응 노트

불러오는 중…