1-Isobutyl-4-(5-nitro-pyridin-2-yl)-piperazine → HCID 24253463, compound

HRID 490081Notes

Reaction equation

HRID 490081 reaction equation
[CH2:1]([N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][N:12]=2)[CH2:7][CH2:6]1)[CH:2]([CH3:4])[CH3:3].[H][H]>CO.[Pd]>[CH2:1]([N:5]1[CH2:10][CH2:9][N:8]([C:11]2[N:12]=[CH:13][C:14]([NH2:17])=[CH:15][CH:16]=2)[CH2:7][CH2:6]1)[CH:2]([CH3:4])[CH3:3]

Participants

5

Reactant 2

HCID 684068771-Isobutyl-4-(5-nitro-pyridin-2-yl)-piperazine2×HCID 178418361HCID 178418361, compound

Product 1

HCID 24253463HCID 24253463, compoundYield 95.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 2.48 g 1-isobutyl-4-(5-nitro-pyridin-2-yl)-piperazine (intermediate 7) and 0.8 g Pd/C (10%) in 30 ml methanol was treated with 1 bar hydrogen at room temperature for 2 h. After filtration the mixture was evaporated to dryness to yield 2.09 g (95%) of the title compound as colorless solid. (m/e): 235.0 (MH+; 100%).

Workup

  1. filtrationAfter filtration the mixture
  2. customwas evaporated to dryness

Sources & evidence

ORD record
ord-394e269e94d347aa8b0780d144b85564
Source dataset
uspto-grants-2009_05
Patent number
US07528135B2

Reaction notes

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