Trifluoroacetic acid → HCID 178434260, compound

HRID 490101Notes

Reaction equation

HRID 490101 reaction equation
[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]3[N:12]=[N:13][CH:14]=[C:15]([N:17]4[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]4)[N:16]=3)[CH:9]=2)[NH:4][N:3]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]3[N:12]=[N:13][CH:14]=[C:15]([N:17]4[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]4)[N:16]=3)[CH:9]=2)[NH:4][N:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178434267HCID 178434267, compound

Product 1

HCID 178434260HCID 178434260, compoundYield 67.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 3-(3-methylindazol-5-yl)-5-(4-Boc-piperazin-1-yl)-[1,2,4]triazine 153 (5.1 mg, 0.013 mmol.) was added a 20% solution of trifluoroacetic acid in DCM. The reaction mixture was stirred at room temperature for 1 hour. The organic solvent was evaporated under reduced pressure. The crude product was purified by RP-HPLC to yield the desired 3-(3-methylindazol-5-yl)-5-(piperazin-1-yl)-[1,2,4]triazine 46 (2.6 mg, 0.0088 mmol.).

Workup

  1. customThe organic solvent was evaporated under reduced pressure
  2. customThe crude product was purified by RP-HPLC

Sources & evidence

ORD record
ord-e09c5f2e60c548feab18d0472945a789
Source dataset
uspto-grants-2009_05
Patent number
US07528132B2

Reaction notes

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