Hydrazine hydrate (1:1) → 4-(6-(methylthio)pyrimidin-4-yl)-1H-pyrazole-3,5-diamine

Participants

Reaction Steps

2-(6-(methylthio)pyrimidin-4-yl)malononitrile (11.4 g, 0.06 mol) was suspended in 150 mL EtOH and hydrazine hydrate (3 mL, 0.06 mol) was added. The reaction mixture was heated to reflux for 3 days. The reaction mixture was concentrated to a solid which was suspended in ethyl acetate (100 mL), and filtered. This solid was dried to give the product, 10.4 g, 46.8 mmol, 78%, ca. 80% pure).

Provenance & Evidence