反应详情

2-(6-(methylthio)pyrimidin-4-yl)malononitrile (11.4 g, 0.06 mol) was suspended in 150 mL EtOH and hydrazine hydrate (3 mL, 0.06 mol) was added. The reaction mixture was heated to reflux for 3 days. The reaction mixture was concentrated to a solid which was suspended in ethyl acetate (100 mL), and filtered. This solid was dried to give the product, 10.4 g, 46.8 mmol, 78%, ca. 80% pure).

1. temperatureThe reaction mixture was heated
2. temperatureto reflux for 3 days
3. concentrationThe reaction mixture was concentrated to a solid which
4. filtrationfiltered
5. customThis solid was dried
6. customto give the product, 10.4 g, 46.8 mmol, 78%, ca. 80% pure)