Trifluoroacetic acid → HCID 67429237, compound

HRID 490124Notes

Reaction equation

HRID 490124 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:8][N:9]([CH3:25])[C:10]([C@@H:12]1[CH2:16][C@H:15]([F:17])[CH2:14][N:13]1C(OC(C)(C)C)=O)=[O:11]>C(Cl)(Cl)Cl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:17][C@@H:15]1[CH2:14][NH:13][C@H:12]([C:10]([N:9]([CH3:25])[CH3:8])=[O:11])[CH2:16]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67428522HCID 67428522, compound

Product 1

HCID 67429237HCID 67429237, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

18 mL of trifluoroacetic acid was added under ice cooling to a 60 mL chloroform solution of 5.98 g of the compound obtained in step 2-3, and the reaction mixture was stirred for 2 hours at the same temperature. After this, the solvent was distilled off under reduced pressure to obtain 12.1 g of residue (colorless oily substance). This compound was used in the following reaction without being purified.

Workup

  1. distillationAfter this, the solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-e5f01b6bea4a4d4699d730a986ef9e6e
Source dataset
uspto-grants-2009_05
Patent number
US07528124B2

Reaction notes

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