反应详情

5.11 g of a mixture (approximately 3:1) of 1,1,2,3,3,3-hexafluoro-1-(diethylamino)propane and 1,2,3,3,3-pentafluoro-1-(diethylamino)-2-propene was added dropwise over a period of 10 minutes, and under ice cooling, to a suspension of 5.33 g of 1-benzyl 2-methyl(2S,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate and 962 mg of sodium fluoride in 53 mL of dichloromethane, after which the reaction mixture was stirred for 16 hours at room temperature. After this, 100 mL of a 5% potassium carbonate aqueous solution was added under ice cooling to the reaction solution, and the reaction mixture was stirred for 30 minutes at the same temperature. After liquid separation, the aqueous layer thus obtained was extracted with chloroform (30 mL×2), and the combined organic layer was washed with 50 mL of saturated brine and dried with magnesium sulfate, after which the drying agent was filtered off and the solvent was distilled off under reduced pressure. The residue thus obtained was subjected to column chromatography (silica gel 60, mobile phase: ethyl acetate/n-hexane=3/7; v/v) to obtain 1.50 g of the titled compound (colorless oil).

1. stirringthe reaction mixture was stirred for 30 minutes at the same temperature
2. customAfter liquid separation
3. customthe aqueous layer thus obtained
4. extractionwas extracted with chloroform (30 mL×2)
5. washthe combined organic layer was washed with 50 mL of saturated brine
6. dry with materialdried with magnesium sulfate
7. filtrationafter which the drying agent was filtered off
8. distillationthe solvent was distilled off under reduced pressure
9. customThe residue thus obtained