HCID 131727436, compound → HCID 57217836, compound

HRID 490131Notes

Reaction equation

HRID 490131 reaction equation
[F:1][CH:2]1[CH2:6][N:5](C(OCC2C=CC=CC=2)=O)[C@H:4]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:3]1>CO.[C].[Pd]>[F:1][CH:2]1[CH2:6][NH:5][C@H:4]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:3]1

Participants

4

Reactant 1

HCID 131727436HCID 131727436, compound

Product 1

HCID 57217836HCID 57217836, compoundYield 96.2%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

1.25 g of the compound obtained in step 5-3 and 250 mg of 10% palladium-carbon were stirred for 1 hour at room temperature and under a hydrogen atmosphere in 12.5 mL of methanol. The insolubles were filtered off and the filtrate was concentrated under reduced pressure to obtain 704 mg of the titled compound (colorless oily substance).

Workup

  1. filtrationThe insolubles were filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-2cbe7a5815764ef9abf645800788a153
Source dataset
uspto-grants-2009_05
Patent number
US07528124B2

Reaction notes

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