HCID 67428575, compound → HCID 45115932, compound

HRID 490138Notes

Reaction equation

HRID 490138 reaction equation
[CH2:1]([NH:3][C:4]([C@@H:6]1[CH2:10][CH:9]([F:11])[CH2:8][N:7]1C(OCC1C=CC=CC=1)=O)=[O:5])[CH3:2]>CO.[C].[Pd]>[CH2:1]([NH:3][C:4](=[O:5])[C@@H:6]1[CH2:10][CH:9]([F:11])[CH2:8][NH:7]1)[CH3:2]

Participants

4

Reactant 1

HCID 67428575HCID 67428575, compound

Product 1

HCID 45115932HCID 45115932, compoundYield 109.2%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

A suspension of 1.80 g of the compound obtained in step 8-1 and 360 mg of 10% palladium-carbon in 36 mL of methanol was stirred for 3 hours at room temperature and under hydrogen atmosphere. The insolubles were filtered off and the reaction mixture was concentrated under reduced pressure to obtain 1.07 g of the titled compound. This compound was used in the following reaction without being purified.

Workup

  1. filtrationThe insolubles were filtered off
  2. concentrationthe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-9160562361dc4d18aac252bfaf5a6439
Source dataset
uspto-grants-2009_05
Patent number
US07528124B2

Reaction notes

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