1-Benzyl-4-(N-Boc-amino)piperidine → 4-(N-Boc-amino)piperidine

HRID 490295Notes

Reaction equation

HRID 490295 reaction equation
[C:1]([O:5][C:6](=[O:21])[NH:7][CH:8]1[CH2:13][CH2:12][N:11](CC2C=CC=CC=2)[CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6](=[O:21])[NH:7][CH:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 44386181-Benzyl-4-(N-Boc-amino)piperidine

Product 1

HCID 7238334-(N-Boc-amino)piperidine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of D6 (10 g, 3.4 mmol) in methanol (150 ml) was hydrogenated at 50 psi in a Parr hydrogenator using 10% Palladium on carbon catalyst (800 mg) for 18 h. Catalyst was filtered off and the filtrate concentrated under reduced pressure to afford the product as a white solid.

Workup

  1. customfor 18 h
  2. filtrationCatalyst was filtered off
  3. concentrationthe filtrate concentrated under reduced pressure

Sources & evidence

ORD record
ord-791ab8199bb048bbb535676d6d60f300
Source dataset
uspto-grants-2009_05
Patent number
US07528151B2

Reaction notes

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