2,3-Dichloropyridine → (R)-1-(3-Chloropyridin-2-yl)pyrrolidin-3-ylamine

HRID 490297Notes

Reaction equation

HRID 490297 reaction equation
Cl[C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][N:3]=1.C(OC(=O)[NH:15][C@@H:16]1[CH2:20][CH2:19][N:18](C2C(C(F)(F)F)=CC=CN=2)[CH2:17]1)(C)(C)C.FC(F)(F)C1C(N2CC[C@@H](N)C2)=NC=CC=1>>[Cl:8][C:7]1[C:2]([N:18]2[CH2:19][CH2:20][C@@H:16]([NH2:15])[CH2:17]2)=[N:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 169882,3-DichloropyridineHCID 67001808[(R)-1-(3-Trifluoromethylpyridin-2-yl)pyrrolidin-3-yl]-carbamic acid tert-butyl esterHCID 68801104(R)-1-(3-Trifluoromethylpyridin-2-yl)pyrrolidin-3-ylamine

Product 1

HCID 67001519(R)-1-(3-Chloropyridin-2-yl)pyrrolidin-3-ylamine

Procedure

The title compound was prepared from 2,3-dichloropyridine and 3R-(+)-3-(tert-butyloxycarbonylamino)pyrrolidine using the procedure outlined for Descriptions D1 and D2.

Sources & evidence

ORD record
ord-cf03203abee6457fae259810bc9e7559
Source dataset
uspto-grants-2009_05
Patent number
US07528151B2

Reaction notes

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