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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 490297Generated: October 30, 2026

2,3-Dichloropyridine → (R)-1-(3-Chloropyridin-2-yl)pyrrolidin-3-ylamine

https://huagongshe.com/reaction/490297

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,3-DichloropyridineHCID 16988—
Reactant[(R)-1-(3-Trifluoromethylpyridin-2-yl)pyrrolidin-3-yl]-carbamic acid tert-butyl esterHCID 67001808—
Reactant(R)-1-(3-Trifluoromethylpyridin-2-yl)pyrrolidin-3-ylamineHCID 68801104—
Product(R)-1-(3-Chloropyridin-2-yl)pyrrolidin-3-ylamineHCID 67001519—

Reaction Steps

The title compound was prepared from 2,3-dichloropyridine and 3R-(+)-3-(tert-butyloxycarbonylamino)pyrrolidine using the procedure outlined for Descriptions D1 and D2.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07528151B2
Source datasetuspto-grants-2009_05
ORD IDord-cf03203abee6457fae259810bc9e7559
Source noteuspto-grants-2009_05