1-(5-(Trifluoromethyl)pyridin-2-yl)piperidin-4-amine → HCID 69066579, compound

HRID 490303Notes

Reaction equation

HRID 490303 reaction equation
FC(F)(F)C1C=CC([N:9]2[CH2:14][CH2:13][CH:12]([NH2:15])[CH2:11][CH2:10]2)=NC=1.Br[C:19]1[S:20][CH:21]=[C:22]([C:24]([F:27])([F:26])[F:25])[N:23]=1.C(OC(=O)N[C@@H]1CCN(C2C(C(F)(F)F)=CC=CN=2)C1)(C)(C)C.FC(F)(F)C1C(N2CC[C@@H](N)C2)=NC=CC=1>>[F:25][C:24]([F:27])([F:26])[C:22]1[N:23]=[C:19]([N:9]2[CH2:14][CH2:13][CH:12]([NH2:15])[CH2:11][CH2:10]2)[S:20][CH:21]=1

Participants

5

Reactant 4

HCID 47782341-(5-(Trifluoromethyl)pyridin-2-yl)piperidin-4-amineHCID 231498872-Bromo-4-(trifluoromethyl)-1,3-thiazoleHCID 67001808[(R)-1-(3-Trifluoromethylpyridin-2-yl)pyrrolidin-3-yl]-carbamic acid tert-butyl esterHCID 68801104(R)-1-(3-Trifluoromethylpyridin-2-yl)pyrrolidin-3-ylamine

Product 1

HCID 69066579HCID 69066579, compound

Procedure

Prepared from D8 and 2-bromo4-trifluoromethylthiazole (J. A. Edwards Ger. Offen., 2252070, 1973) in a manner similar to that described in D1 and D2. The following were prepared using methods described above and in a manner similar to that of D18:

Workup

  1. customThe following were prepared

Sources & evidence

ORD record
ord-a26077184d90414ea295d68383d97a35
Source dataset
uspto-grants-2009_05
Patent number
US07528151B2

Reaction notes

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