反应详情

To 2-acetamidophenol (90.5 mg, 0.598 mmol) and cesium carbonate (234 mg, 0.718 mmol) was added [(2R)-2-methyloxiranyl]methyl 4-methylbenzene-sulfonate (145 mg, 0.598 mmol) dissolved in DMF (1 ml). The mixture was stirred at room temperature for four hours and then partitioned between ethyl-acetate and water. After extraction the combined organic phases were dried and concentrated in vacuo. The residue was purified on silica (Heptane/EtOAc 3:1-2:1) to give 63 mg (48%) of the title compound.

1. custompartitioned between ethyl-acetate and water
2. extractionAfter extraction the combined organic phases
3. customwere dried
4. concentrationconcentrated in vacuo
5. customThe residue was purified on silica (Heptane/EtOAc 3:1-2:1)