2-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) → 5-Methyl-4-(2'-trifluoromethoxy-biphenyl-4-yloxymethyl)-furan-2-carboxylic acid

HRID 490379Notes

Reaction equation

HRID 490379 reaction equation
I[C:2]1[CH:18]=[CH:17][C:5]([O:6][CH2:7][C:8]2[CH:9]=[C:10]([C:14]([OH:16])=[O:15])[O:11][C:12]=2[CH3:13])=[CH:4][CH:3]=1.[F:19][C:20]([F:32])([F:31])[O:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1B(O)O>>[CH3:13][C:12]1[O:11][C:10]([C:14]([OH:16])=[O:15])=[CH:9][C:8]=1[CH2:7][O:6][C:5]1[CH:17]=[CH:18][C:2]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=2[O:21][C:20]([F:19])([F:32])[F:31])=[CH:3][CH:4]=1

Participants

3

Reactant 2

HCID 27772042-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride)HCID 184446544-(4-Iodo-phenoxymethyl)-5-methyl-furan-2-carboxylic acid

Product 1

HCID 184446025-Methyl-4-(2'-trifluoromethoxy-biphenyl-4-yloxymethyl)-furan-2-carboxylic acid

Procedure

Compound (115) was prepared from compound (26) and (2-trifluoromethoxy-phenyl)-boronic acid by adapting the procedure of Example 27B. LC/MS System B; Rt=1.97 mins, m/z (ES−)=391 (M−H for C20H15F3O5).

Sources & evidence

ORD record
ord-20e756d4c4f6456b84e5078f72255a42
Source dataset
uspto-grants-2009_05
Patent number
US07528157B2

Reaction notes

Loading…