Methyl 4-(chloromethyl)-5-methylfuran-2-carboxylate → 4-(4'-Difluoromethoxy-biphenyl-4-ylaminomethyl)-5-methylfuran-2-carboxylic acid methyl ester

HRID 490410Notes

Reaction equation

HRID 490410 reaction equation
[CH3:1][O:2][C:3]([C:5]1[O:6][C:7]([CH3:12])=[C:8]([CH2:10]Cl)[CH:9]=1)=[O:4].[F:13][CH:14]([F:29])[O:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:27]=[CH:26][C:25]([NH2:28])=[CH:24][CH:23]=2)=[CH:18][CH:17]=1>C(#N)C>[CH3:1][O:2][C:3]([C:5]1[O:6][C:7]([CH3:12])=[C:8]([CH2:10][NH:28][C:25]2[CH:26]=[CH:27][C:22]([C:19]3[CH:20]=[CH:21][C:16]([O:15][CH:14]([F:13])[F:29])=[CH:17][CH:18]=3)=[CH:23][CH:24]=2)[CH:9]=1)=[O:4]

Participants

4

Reactant 2

HCID 914782Methyl 4-(chloromethyl)-5-methylfuran-2-carboxylateHCID 184446604'-Difluoromethoxy-biphenyl-4-ylamine

Product 1

HCID 588241804-(4'-Difluoromethoxy-biphenyl-4-ylaminomethyl)-5-methylfuran-2-carboxylic acid methyl ester

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Compound (170) was prepared from compounds (159) and (169) by adapting the procedure of Example 38(d). (420 mg). LC/MS System A; Rt=4.00 mins, m/z (ES+)=388 (M+H) and 429 (M+H acetonitrile adduct) for C21H19F2NO3.

Sources & evidence

ORD record
ord-e52b011f63674c7ebc855c9b8b9dced4
Source dataset
uspto-grants-2009_05
Patent number
US07528157B2

Reaction notes

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