HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-(chloromethyl)-5-methylfuran-2-carboxylate → 4-(4'-Difluoromethoxy-biphenyl-4-ylaminomethyl)-5-methylfuran-2-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-(chloromethyl)-5-methylfuran-2-carboxylate | HCID 914782 | — |
| Reactant | 4'-Difluoromethoxy-biphenyl-4-ylamine | HCID 18444660 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-(4'-Difluoromethoxy-biphenyl-4-ylaminomethyl)-5-methylfuran-2-carboxylic acid methyl ester | HCID 58824180 | — |
Reaction Steps
Compound (170) was prepared from compounds (159) and (169) by adapting the procedure of Example 38(d). (420 mg). LC/MS System A; Rt=4.00 mins, m/z (ES+)=388 (M+H) and 429 (M+H acetonitrile adduct) for C21H19F2NO3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07528157B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-e52b011f63674c7ebc855c9b8b9dced4 |
| Source note | uspto-grants-2009_05 |