反应详情

Lithium aluminum hydride (1.7 g, 45 mmol) was added to 5-dimethylcarbamoylmethoxy-1H-indole-2-carboxylic acid ethyl ester (1.4 g, 4.8 mmol) in tetrahydrofuran (80 mL). The mixture was stirred at room temperature for 4 hours and cooled to 0° C. It was then quenched with water (1.7 mL), 15% sodium hydroxide (1.7 mL) and water (1.7 mL). The precipitate was filtered off and the filtrate was concentrated to give 0.6 g (54%) of [5-(2-dimethylamino-ethoxy)-1H-indol-2-yl]-methanol.

1. temperaturecooled to 0° C
2. customIt was then quenched with water (1.7 mL), 15% sodium hydroxide (1.7 mL) and water (1.7 mL)
3. filtrationThe precipitate was filtered off
4. concentrationthe filtrate was concentrated