反应详情

2-[5-Methoxy-6-(2-methoxyethoxy)-1-methyl-1H-indol-3-yl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine is prepared by following the procedure described in example 147d, but using 0.195 g of 1-bromo-2-methoxyethane instead of 1-chloro-2-bromoethane used in example 147d, and 0.224 g of 2-[1-methyl-5-methoxy-6-hydroxyl-1H-indol-3-yl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine. After purification by flash-pack chromatography (silica, 80/20 by volume ethyl acetate/cyclohexane as eluents, argon), 0.121 g of 2-[5-methoxy-6-(2-methoxyethoxy)-1-methyl-1H-indol-3-yl]-1H-pyrrolo[2,3-b]pyridine is obtained, the characteristics of which are as follows:

1. customAfter purification by flash-pack chromatography (silica, 80/20 by volume ethyl acetate/cyclohexane as eluents, argon)