HRID490578

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CC(C)(C)OC(=O)N1CC(N(Cc2ccccc2)C(=O)OCC(Cl)(Cl)Cl)CC1C(=O)N1CCN(c2ccccc2C#N)CC1

HCID67546549

未命名化合物

PRODUCTS

生成物

结构：N#Cc1ccccc1N1CCN(C(=O)C2CC(N(Cc3ccccc3)C(=O)OCC(Cl)(Cl)Cl)CN2)CC1

HCID67547167

未命名化合物

PROCEDURE

实验过程

A mixture of 2-[4-(2-cyano-phenyl)-piperazine-1-carbonyl]-4-[(benzyl)-(2,2,2-trichloroethoxycarbonyl)-amino]-pyrrolidine-1-carboxylic acid tert-butyl ester and CF3COOH are stirred at rt for about 5 h, and then concentrated to give {5-[4-(2-cyano-phenyl)-piperazine-1-carbonyl]-pyrrolidin-3-yl}-(benzyl)-carbamic acid 2,2,2-trichloro-ethyl ester (22).

WORKUP

后处理

concentrationconcentrated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9051a48db60844f48442177a54b85633
来源数据集: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07528136B2
来源说明: uspto-grants-2009_05

反应 SMILES

C(OC([N:8]1[CH2:12][CH:11]([N:13]([CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:14]([O:16][CH2:17][C:18]([Cl:21])([Cl:20])[Cl:19])=[O:15])[CH2:10][CH:9]1[C:29]([N:31]1[CH2:36][CH2:35][N:34]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=2[C:43]#[N:44])[CH2:33][CH2:32]1)=[O:30])=O)(C)(C)C.C(O)(C(F)(F)F)=O>>[Cl:21][C:18]([Cl:19])([Cl:20])[CH2:17][O:16][C:14](=[O:15])[N:13]([CH:11]1[CH2:10][CH:9]([C:29]([N:31]2[CH2:32][CH2:33][N:34]([C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=3[C:43]#[N:44])[CH2:35][CH2:36]2)=[O:30])[NH:8][CH2:12]1)[CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1