HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Azide → 1-Tert-butyl 2-methyl 4-azidopyrrolidine-1,2-dicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 4-Iodo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester | HCID 67547214 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-Tert-butyl 2-methyl 4-azidopyrrolidine-1,2-dicarboxylate | HCID 14772683 | — |
Reaction Steps
To a solution of 4-iodo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester in DMF is added NaN3, the resulting mixture is heated to about 65 centigrade and stirred overnight. The mixture is diluted, extracted and dried. After removal of solvent, the residue is purified to give 4-azido-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl (8).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07528136B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-46b6fa08834c4401aee658517b96f5ff |
| Source note | uspto-grants-2009_05 |