反应详情

To a solution of 4-iodo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester in DMF is added NaN3, the resulting mixture is heated to about 65 centigrade and stirred overnight. The mixture is diluted, extracted and dried. After removal of solvent, the residue is purified to give 4-azido-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl (8).

1. temperaturethe resulting mixture is heated to about 65 centigrade
2. additionThe mixture is diluted
3. extractionextracted
4. customdried
5. customAfter removal of solvent
6. customthe residue is purified