HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 1-Tert-butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 1-Tert-butyl 2-methyl 4-azidopyrrolidine-1,2-dicarboxylate | HCID 14772683 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-Tert-butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate | HCID 4913064 | — |
Reaction Steps
A solution of 4-azido-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester, THF and PPh3 and water is refluxed for about 6 hours and then concentrated. The residue is dissolved in Et2O and treated with HCl. The aqueous layer is extracted, washed, dried and concentrated to afford 4-amino-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (32).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07528136B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-ca3423770c7d4ee4912b5b9c85140986 |
| Source note | uspto-grants-2009_05 |