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HRID490585

反应详情

EQUATION

反应方程式

HRID 490585 的结构方程式

REACTANTS

反应物

3
结构：C1CCOC1
HCID8028

Tetrahydrofuran

C4H8O

结构：c1ccc(P(c2ccccc2)c2ccccc2)cc1
HCID11776

Triphenylphosphine

C18H15P

结构：COC(=O)C1CC(N=[N+]=[N-])CN1C(=O)OC(C)(C)C
HCID14772683

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)C1CC(N)CN1C(=O)OC(C)(C)C
HCID4913064

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

A solution of 4-azido-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester, THF and PPh3 and water is refluxed for about 6 hours and then concentrated. The residue is dissolved in Et2O and treated with HCl. The aqueous layer is extracted, washed, dried and concentrated to afford 4-amino-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (32).

WORKUP

后处理

  1. concentrationconcentrated
  2. dissolutionThe residue is dissolved in Et2O
  3. additiontreated with HCl
  4. extractionThe aqueous layer is extracted
  5. washwashed
  6. customdried
  7. concentrationconcentrated