HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenylpiperazine → 4-Phenylpiperazine-1-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenylpiperazine | HCID 7096 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Phenylpiperazine-1-carbaldehyde | HCID 259459 | — |
Reaction Steps
A mixture of 1-benzyl-4-[(benzyl)-troc-amino]-pyrrolidine carboxylic acid, EDCI, HOBT, Et3N and a corresponding phenylpiperazine in DCM is stirred at room temperature overnight. Concentration of the mixture give the crude 1-benzyl-[4-(benzyl)-troc-amino]-pyrrolidin-2-yl}-[4-(phenyl)-piperazin-1-yl]-methanone (38).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07528136B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-bd61eb90b39c4021a1e2dd856f79338f |
| Source note | uspto-grants-2009_05 |