3,4-Dichlorobenzyl chloride → HCID 60295281, compound

HRID 490641Notes

Reaction equation

HRID 490641 reaction equation
[CH3:1][O:2][C:3]([CH:5]1[CH2:9][CH:8]([OH:10])[CH2:7][NH:6]1)=[O:4].[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18]Cl)=[CH:14][C:13]=1[Cl:20]>>[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([OH:10])[CH2:7][N:6]1[CH2:18][C:15]1[CH:16]=[CH:17][C:12]([Cl:11])=[C:13]([Cl:20])[CH:14]=1)=[O:4]

Participants

3

Reactant 2

HCID 76093,4-Dichlorobenzyl chlorideHCID 549381Methyl 4-hydroxypyrrolidine-2-carboxylate

Product 1

HCID 60295281HCID 60295281, compoundYield 70%

Procedure

As described for Example 64a, 4-hydroxy-pyrrolidine-2-carboxylic acid methyl ester (10 mmol) was converted, using 1,2-dichloro-4-chloromethyl-benzene instead of 1-chloro-3-chloromethyl-benzene, to the title compound (2.14 g) in 70% yield as yellow oil.

Sources & evidence

ORD record
ord-461c0e026cbe44ea8bbcf5fe7848b17c
Source dataset
uspto-grants-2009_05
Patent number
US07528136B2

Reaction notes

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