2-Chlorobenzaldehyde → HCID 67546470, compound

HRID 490654Notes

Reaction equation

HRID 490654 reaction equation
[CH2:1]([N:8]1[CH2:12][CH:11]([NH:13][CH3:14])[CH2:10][CH:9]1[C:15]([N:17]1[CH2:22][CH2:21][N:20]([C:23]2[CH:30]=[CH:29][CH:28]=[CH:27][C:24]=2[C:25]#[N:26])[CH2:19][CH2:18]1)=[O:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:31][C:32]1[CH:39]=[CH:38][CH:37]=[CH:36][C:33]=1[CH:34]=O>>[CH2:1]([N:8]1[CH2:12][C@@H:11]([N:13]([CH2:34][C:33]2[CH:36]=[CH:37][CH:38]=[CH:39][C:32]=2[Cl:31])[CH3:14])[CH2:10][C@H:9]1[C:15]([N:17]1[CH2:22][CH2:21][N:20]([C:23]2[CH:30]=[CH:29][CH:28]=[CH:27][C:24]=2[C:25]#[N:26])[CH2:19][CH2:18]1)=[O:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 69962-ChlorobenzaldehydeHCID 57674255HCID 57674255, compound

Product 1

HCID 67546470HCID 67546470, compound

Procedure

As described for Example 75d, 2-[4-(1-benzyl-4-methylamino-pyrrolidine-2-carbonyl)-piperazin-1-yl]-benzonitrile was converted, using 2-chlorobenzaldehyde instead of 3,4-dichlorobenzaldehyde, to the title compound. MS m/e=528.4 [M+H]+.

Sources & evidence

ORD record
ord-6395eef2d26c493e9f8de4f0e99ec572
Source dataset
uspto-grants-2009_05
Patent number
US07528136B2

Reaction notes

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