反应详情

To a solution of 4-iodo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (20 mmol, 1 equiv) in DMF was added NaN3 (2.5 equiv, 50 mmol), the resulting mixture was heated to 65 centigrade and stirred overnight. The mixture was diluted with water, extracted with AcOEt and dried over Na2SO4. After removal of solvent, the residue was purified by chromatography on silica gel to give title product (4.94 g) as colorless oil in 90% yield. MS m/e=271.5 [M+H]+.

1. temperaturethe resulting mixture was heated to 65 centigrade
2. extractionextracted with AcOEt
3. dry with materialdried over Na2SO4
4. customAfter removal of solvent
5. customthe residue was purified by chromatography on silica gel