Cesium fluoride → HCID 57675475, compound

HRID 490683Notes

Reaction equation

HRID 490683 reaction equation
[CH2:1]([O:3][C:4](=[O:26])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([S:15][Si](C(C)C)(C(C)C)C(C)C)=[CH:12][CH:13]=2)[CH:8]=[CH:7]1)[CH3:2].[F-].[Cs+]>CN1CCCC1=O>[CH2:1]([O:3][C:4](=[O:26])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([SH:15])=[CH:12][CH:13]=2)[CH:8]=[CH:7]1)[CH3:2]

Participants

4

Reactant 2

HCID 25953Cesium fluorideHCID 69058310HCID 69058310, compound

Product 1

HCID 57675475HCID 57675475, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

(5-Triisopropylsilanylsulfanyl-indol-1-yl)-acetic acid ethyl ester (60 mg, 0.1621 mmol) is dissolved in n-methylpyrrolidinone (NMP) (5 mL) and cesium fluoride (0.243 mmol) is added. The reaction is allowed to stir at room temperature until complete. This solution may be used in the coupling step (next) without further purification.

Workup

  1. customThis solution may be used in the coupling step (next) without further purification

Sources & evidence

ORD record
ord-081c186d1e034e36ac9942bea1069052
Source dataset
uspto-grants-2009_05
Patent number
US07528160B2

Reaction notes

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