反应详情

温度

60 °C

A solution of 7-hydroxy-3,4-dihydro-1H-quinolin-2-one (310 mg, 1.90 mmol) and 5-chloromethyl-4-methyl-2-(4-trifluoromethyl-phenyl)-thiazole (666 mg, 2.28 mmol) in DMF (3.0 mL) is treated with Cs2CO3 (1.25 g, 3.80 mmol). The resulting suspension is heated at 60° C. for 5 hours and then quenched with water dropwise. The mixture is extracted with EtOAc (40 mL×3) and the combined organics are dried (Na2SO4), concentrated to a suspension. It is then filtered and the solid is rinsed with EtOAc (2 mL) and dried under vacuum to obtain pure product (233 mg, 29%).

1. customquenched with water dropwise
2. extractionThe mixture is extracted with EtOAc (40 mL×3)
3. dry with materialthe combined organics are dried (Na2SO4)
4. concentrationconcentrated to a suspension
5. filtrationIt is then filtered
6. washthe solid is rinsed with EtOAc (2 mL)
7. customdried under vacuum