反应详情

Matairesinol (500 mg, 1.4 mmol) was dissolved in 30 ml pyridine. To the solution succinic anhydride (700 mg, 7 mmol) was added in small portions. The temperature was adjusted to 50° C. and the mixture was stirred for 24 h. The solvent was removed under reduced-pressure and the residue dissolved in dichloromethane and extracted first with slightly basic water. The water phase was then acidified with 10% HCl and extracted with dichloromethane. The organic phases were combined, concentrated and chromatographed on a silica column using CHCl3:EtOAc (1:1) as eluent. The fractions containing the product were combined and the solvents were removed.

1. customwas adjusted to 50° C.
2. customThe solvent was removed under reduced-pressure
3. dissolutionthe residue dissolved in dichloromethane
4. extractionextracted first with slightly basic water
5. extractionextracted with dichloromethane
6. concentrationconcentrated
7. customchromatographed on a silica column
8. additionThe fractions containing the product
9. customthe solvents were removed