Succinic anhydride → Matairesinol Succinate

Participants

Reaction Steps

Matairesinol (500 mg, 1.4 mmol) was dissolved in 30 ml pyridine. To the solution succinic anhydride (700 mg, 7 mmol) was added in small portions. The temperature was adjusted to 50° C. and the mixture was stirred for 24 h. The solvent was removed under reduced-pressure and the residue dissolved in dichloromethane and extracted first with slightly basic water. The water phase was then acidified with 10% HCl and extracted with dichloromethane. The organic phases were combined, concentrated and chromatographed on a silica column using CHCl3:EtOAc (1:1) as eluent. The fractions containing the product were combined and the solvents were removed.

Provenance & Evidence