HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 490907Generated: October 30, 2026
Hydrochloric Acid → 1-Ethyl-6-methyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carbohydrazide hydrochloride
https://huagongshe.com/reaction/490907
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,1-Dimethylethyl 2-{[1-ethyl-6-methyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]carbonyl}hydrazinecarboxylate | HCID 57675222 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-Ethyl-6-methyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carbohydrazide hydrochloride | HCID 67529055 | — |
Reaction Steps
Intermediate 62 (0.19 g, 0.46 mmol) was dissolved in 4M hydrogen chloride in dioxane (5 ml) and the reaction mixture stirred overnight at 20° C. Concentration in vacuo afforded Intermediate 63 as a white solid (0.161 g). LCMS showed MH+=319; TRET=1.72 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07528148B2 |
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| Source dataset | uspto-grants-2009_05 |
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| ORD ID | ord-ddaeac8eb3364d40b07caaef856891fb |
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| Source note | uspto-grants-2009_05 |
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