Sodium → HCID 57675686, compound

HRID 490956Notes

Reaction equation

HRID 490956 reaction equation
[C:1]1([S:7]([C:10]2[CH:19]=[C:18]3[C:13]([C:14](=[O:20])[CH2:15][CH2:16][O:17]3)=[CH:12][CH:11]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Na]>CO>[C:1]1([S:7]([C:10]2[CH:19]=[C:18]3[C:13]([CH:14]([OH:20])[CH2:15][CH2:16][O:17]3)=[CH:12][CH:11]=2)(=[O:9])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 5360545SodiumHCID 57675682HCID 57675682, compound

Product 1

HCID 57675686HCID 57675686, compoundYield 96.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

7-Benzenesulfonyl-chroman-4-one (500 mg, 1.73 mmol) was dissolved in 15 mL MeOH, and sodium borohidride (72 mg, 1.9 mmol) was added. The reaction mixture was stirred at room temperature for one hour, and was then partitioned between water and ethyl acetate. The combined organic layers were dried over MgSO4, and solvent was removed under reduced pressure to give 483 mg of crude 7-benzenesulfonyl-chroman-4-ol. MS: 291 (M+H)+.

Workup

  1. customwas then partitioned between water and ethyl acetate
  2. dry with materialThe combined organic layers were dried over MgSO4, and solvent
  3. customwas removed under reduced pressure

Sources & evidence

ORD record
ord-fdf78cb6e12146d19787541d444b8bf6
Source dataset
uspto-grants-2009_05
Patent number
US07528250B2

Reaction notes

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