Thionyl Chloride → HCID 57675685, compound

HRID 490957Notes

Reaction equation

HRID 490957 reaction equation
[C:1]1([S:7]([C:10]2[CH:19]=[C:18]3[C:13]([CH:14](O)[CH2:15][CH2:16][O:17]3)=[CH:12][CH:11]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:23])=O>C1(C)C=CC=CC=1>[C:1]1([S:7]([C:10]2[CH:19]=[C:18]3[C:13]([CH:14]([Cl:23])[CH2:15][CH2:16][O:17]3)=[CH:12][CH:11]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 57675686HCID 57675686, compound

Product 1

HCID 57675685HCID 57675685, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

7-Benzenesulfonyl-chroman-4-ol (483 mg, 1.66 mmol) was dissoved in 10 mL toluene, and 182 uL (02.49 mmol) of thionyl chloride was added. The reaction was refluxed for two hours, and then cooled to room temperature. Solvent was removed under reduced pressure to yield 7-benzenesulfonyl-4-chloro-chroman (512 mg) as a crude oil. MS: 308 (M+H)+.

Workup

  1. temperatureThe reaction was refluxed for two hours
  2. customSolvent was removed under reduced pressure

Sources & evidence

ORD record
ord-0b286a4281174c64a73f99c4edcc8452
Source dataset
uspto-grants-2009_05
Patent number
US07528250B2

Reaction notes

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