反应详情

温度

22 °C

5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]thio]imidazo[4,5-b]pyridine (100 mg, 0.303 mmol) and (1R,2S)-(+)-1-amino-2-indanol (22.8 mg, 0.151 mmol) are solubilised in anhydrous pyridine (0.65 mL); titanium isopropoxide (IV) (22 μL, 0.076 mmol) is added under stirring at 22° C., followed by cumene hydroperoxide (80%, 65 μL, 0.352 mmol).