Lithium Hydroxide → HCID 68673613, compound

HRID 491175Notes

Reaction equation

[CH2:1]([O:8][C:9]1[C:41]([CH3:42])=[CH:40][C:12]([CH2:13][C@@H:14]([CH2:19][C:20](=[O:39])[N:21]2[CH2:26][CH2:25][CH:24]([N:27]3[CH2:33][CH2:32][C:31]4[CH:34]=[CH:35][CH:36]=[CH:37][C:30]=4[NH:29][C:28]3=[O:38])[CH2:23][CH2:22]2)[C:15]([O:17]C)=[O:16])=[CH:11][C:10]=1[O:43][CH3:44])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Li+].[OH-]>>[CH2:1]([O:8][C:9]1[C:41]([CH3:42])=[CH:40][C:12]([CH2:13][C@@H:14]([CH2:19][C:20](=[O:39])[N:21]2[CH2:22][CH2:23][CH:24]([N:27]3[CH2:33][CH2:32][C:31]4[CH:34]=[CH:35][CH:36]=[CH:37][C:30]=4[NH:29][C:28]3=[O:38])[CH2:25][CH2:26]2)[C:15]([OH:17])=[O:16])=[CH:11][C:10]=1[O:43][CH3:44])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 69064943HCID 69064943, compound

Product 1

HCID 68673613HCID 68673613, compound

Procedure

Prepared analogously to Example 7g from 7.83 g (13.1 mmol) methyl(S)-2-(4-benzyloxy-3-methoxy-5-methyl-benzyl)-4-oxo-4-[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-butanoate and 1.25 g (52.2 mmol) LiOH.

Sources & evidence

ORD record: ord-15dc7c99785d4f1e909418e787809851
Source dataset: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07528129B2

Reaction notes

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