Trifluoroacetic acid → HCID 16723095, compound

HRID 491207Notes

Reaction equation

HRID 491207 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][S:15]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([NH:24][C:25]3[C:30]([CH3:31])=[CH:29][N:28]=[C:27]([NH:32][C:33]4[CH:38]=[CH:37][C:36]([N:39]5[CH2:44][CH2:43][N:42]([CH3:45])[CH2:41][CH2:40]5)=[CH:35][CH:34]=4)[N:26]=3)[CH:19]=2)(=[O:17])=[O:16])[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:31][C:30]1[C:25]([NH:24][C:20]2[CH:19]=[C:18]([S:15]([NH:14][CH:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)(=[O:17])=[O:16])[CH:23]=[CH:22][CH:21]=2)=[N:26][C:27]([NH:32][C:33]2[CH:38]=[CH:37][C:36]([N:39]3[CH2:40][CH2:41][N:42]([CH3:45])[CH2:43][CH2:44]3)=[CH:35][CH:34]=2)=[N:28][CH:29]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57675121HCID 57675121, compound

Product 1

HCID 16723095HCID 16723095, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Intermediate 47 (0.2 g, 0.32 mmol) was diluted with DCM (10 mL) and treated with TFA (0.3 mL). After 3 h, reaction solvents removed and resulting residue was purified by HPLC (0.01 g, 6%).

Workup

  1. customreaction solvents
  2. customremoved
  3. customresulting residue
  4. customwas purified by HPLC (0.01 g, 6%)

Sources & evidence

ORD record
ord-e2e72453da9043368ff2533ade24fd9c
Source dataset
uspto-grants-2009_05
Patent number
US07528143B2

Reaction notes

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