HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl-3-nitrobiphenyl-4-malonate → 3-Nitro-biphenyl-4-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl-3-nitrobiphenyl-4-malonate | HCID 10711410 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 3-Nitro-biphenyl-4-acetic acid | HCID 10491360 | 80% |
Reaction Steps
Crude dimethyl-3-nitrobiphenyl-4-malonate was heated to reflux in 30 mL of 6N hydrochloric acid for 24 hours. The precipitate was collected by filtration, washed with water and dried to give 4.5 g (80% based on-4-fluoro-3-nitrobiphenyl) of 3-nitrobiphenyl-4-acetic acid as a cream colored solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06706709B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-635cd97cf01c48abbd4d2dbe2ac19294 |
| Source note | uspto-grants-2004_03 |