反应详情

Tetrakis(triphenylphosphine)palladium (1 g) was added to a mixture of 5 g of 4-methoxyphenylboronic acid, 6.6 g of 5-bromo-2-fluoronitrobenzene and 30 mL of 2M sodium carbonate solution in 50 mL of toluene and 50 mL of ethanol. The mixture was heated to reflux for 2 hours, concentrated, and the residue extracted twice with ethyl acetate. The ethyl acetate layer was washed with water, brine, dried, and concentrated to give a brown oily solid. The solid was purified by column chromatography on silica gel in 5% ethyl acetate in hexane to give crude-4-fluoro-4′-methoxy-3-nitrobiphenyl as a pale yellow solid.

1. temperatureThe mixture was heated
2. temperatureto reflux for 2 hours
3. concentrationconcentrated
4. extractionthe residue extracted twice with ethyl acetate
5. washThe ethyl acetate layer was washed with water, brine
6. customdried
7. concentrationconcentrated
8. customto give a brown oily solid
9. customThe solid was purified by column chromatography on silica gel in 5% ethyl acetate in hexane