反应详情

温度

100 °C

Iron chips (3.6 g) were added in one portion to 7.2 g of 4′-methoxy-3-nitrobiphenyl-4-acetic acid in 50 mL of glacial acetic acid and heated at 100° C. overnight. The reaction mixture was concentrated to dryness, sonicated in ethyl acetate and filtered to remove the insolubles. The filtrate was washed twice with 1 N hydrochloric acid, brine, dried over anhydrous sodium sulfate and concentrated to give 2.7 g (54% yield based on 5-bromo-2-fluoronitrobenzene) of 6-(4-methoxyphenyl)-2-oxindole as a rose colored solid.

1. concentrationThe reaction mixture was concentrated to dryness
2. customsonicated in ethyl acetate
3. filtrationfiltered
4. customto remove the insolubles
5. washThe filtrate was washed twice with 1 N hydrochloric acid, brine
6. dry with materialdried over anhydrous sodium sulfate
7. concentrationconcentrated