反应详情

A solution of 1,2-dibromoethane (15.4 g, TCI) in acetone (50 ml) was added with potassium carbonate (13.6 g), and added dropwise with a solution of methyl 3-hydroxybenzoate (5.0 g, TCI) in acetone (20 ml), and then the mixture was refluxed for 24 hours by heating. The insoluble solid was removed by filtration, and then the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (Flash, hexane:ethyl acetate=3:1) to obtain the title compound (Intermediate id-01, 3.18 g).

1. temperaturethe mixture was refluxed for 24 hours
2. temperatureby heating
3. customThe insoluble solid was removed by filtration
4. concentrationthe filtrate was concentrated under reduced pressure
5. customThe residue was purified by column chromatography (Flash, hexane:ethyl acetate=3:1)