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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 491437Generated: October 26, 2026

Methanesulfonyl chloride → (4aS,8aR)-4-(3,4-Diethoxyphenyl)-2-(1-methanesulfonyl-piperidin-4-yl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one

https://huagongshe.com/reaction/491437

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanesulfonyl chlorideHCID 31297—
Reactant(4aS,8aR)-4-(3,4-Diethoxyphenyl)-2-[1-(toluene-4-sulfonyl)-piperidin-4-yl]-4a,5,8,8a-tetrahydro-2H-phthalazin-1-oneHCID 10175016—
Product(4aS,8aR)-4-(3,4-Diethoxyphenyl)-2-(1-methanesulfonyl-piperidin-4-yl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-oneHCID 10310924—

Reaction Steps

Prepared from methanesulfonylchloride and starting compound A2 as described for compound 1. Crystallisation from methanol/water. M.p. 99-102° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07531540B2
Source datasetuspto-grants-2009_05
ORD IDord-d37e4281f2e9484094012e1f14c5b2d0
Source noteuspto-grants-2009_05