Methanesulfonyl chloride → (4aS,8aR)-4-(3,4-Diethoxyphenyl)-2-(1-methanesulfonyl-piperidin-4-yl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one

HRID 491437Notes

Reaction equation

HRID 491437 reaction equation
CS(Cl)(=O)=O.[CH2:6]([O:8][C:9]1[CH:10]=[C:11]([C:18]2[C@@H:27]3[C@@H:22]([CH2:23][CH:24]=[CH:25][CH2:26]3)[C:21](=[O:28])[N:20]([CH:29]3[CH2:34][CH2:33][N:32]([S:35]([C:38]4C=CC(C)=CC=4)(=[O:37])=[O:36])[CH2:31][CH2:30]3)[N:19]=2)[CH:12]=[CH:13][C:14]=1[O:15][CH2:16][CH3:17])[CH3:7]>>[CH2:6]([O:8][C:9]1[CH:10]=[C:11]([C:18]2[C@@H:27]3[C@@H:22]([CH2:23][CH:24]=[CH:25][CH2:26]3)[C:21](=[O:28])[N:20]([CH:29]3[CH2:34][CH2:33][N:32]([S:35]([CH3:38])(=[O:36])=[O:37])[CH2:31][CH2:30]3)[N:19]=2)[CH:12]=[CH:13][C:14]=1[O:15][CH2:16][CH3:17])[CH3:7]

Participants

3

Procedure

Prepared from methanesulfonylchloride and starting compound A2 as described for compound 1. Crystallisation from methanol/water. M.p. 99-102° C.

Workup

  1. customCrystallisation from methanol/water

Sources & evidence

ORD record
ord-d37e4281f2e9484094012e1f14c5b2d0
Source dataset
uspto-grants-2009_05
Patent number
US07531540B2

Reaction notes

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