HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 491457Generated: October 26, 2026
Hydrochloric Acid → 2,6-Dichloro-3-fluoroacetophenone
https://huagongshe.com/reaction/491457
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4-(2-(tert-butoxycarbonyl)hydrazinyl)piperidine-1-carboxylate | HCID 20824232 | — |
| Product | 2,6-Dichloro-3-fluoroacetophenone | HCID 22311317 | — |
Reaction Steps
A mixture of 0.1 mole of 4-(N′-tert-Butoxycarbonyl-hydrazino)-piperidine-1-carboxylic acid tert-butyl ester (starting compound A6) and 150 ml of concentrated hydrochloric acid is heated at 90° C. for 60 min after which the clear solution is evaporated. The residue is washed with tetrahydrofurane, filtered off and dried under vacuum. M.p. 256-259° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07531540B2 |
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| Source dataset | uspto-grants-2009_05 |
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| ORD ID | ord-24b316de88374ecdbf55fa6f5cd3684c |
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| Source note | uspto-grants-2009_05 |
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