Hydrochloric Acid → 2,6-Dichloro-3-fluoroacetophenone

HRID 491457Notes

Reaction equation

HRID 491457 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][NH:15]C(OC(C)(C)C)=O)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:23]>>[ClH:23].[ClH:23].[NH:8]1[CH2:13][CH2:12][CH:11]([NH:14][NH2:15])[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 20824232Tert-butyl 4-(2-(tert-butoxycarbonyl)hydrazinyl)piperidine-1-carboxylate2×

Product 1

HCID 223113172,6-Dichloro-3-fluoroacetophenone

Conditions

Temperature
90 °C

Procedure

A mixture of 0.1 mole of 4-(N′-tert-Butoxycarbonyl-hydrazino)-piperidine-1-carboxylic acid tert-butyl ester (starting compound A6) and 150 ml of concentrated hydrochloric acid is heated at 90° C. for 60 min after which the clear solution is evaporated. The residue is washed with tetrahydrofurane, filtered off and dried under vacuum. M.p. 256-259° C.

Workup

  1. customis evaporated
  2. washThe residue is washed with tetrahydrofurane
  3. filtrationfiltered off
  4. customdried under vacuum

Sources & evidence

ORD record
ord-24b316de88374ecdbf55fa6f5cd3684c
Source dataset
uspto-grants-2009_05
Patent number
US07531540B2

Reaction notes

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