Hydrogen chloride-ethyl acetate → HCID 131727442, compound

HRID 491465Notes

Reaction equation

HRID 491465 reaction equation
C(OC([N:8]1[CH2:28][CH2:27][C:11]2([C:15](=[O:16])[N:14]([CH2:17][CH2:18][O:19]C3CCCCO3)[C:13](=[O:26])[CH2:12]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:29].C(OCC)(=O)C>C(OCC)(=O)C.CCO>[ClH:29].[OH:19][CH2:18][CH2:17][N:14]1[C:13](=[O:26])[CH2:12][C:11]2([CH2:27][CH2:28][NH:8][CH2:9][CH2:10]2)[C:15]1=[O:16]

Participants

5

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 57678392HCID 57678392, compound

Product 1

HCID 131727442HCID 131727442, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of crude 1,3-dioxo-2-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester (1.6 g) in ethyl acetate (1 ml), EtOH (1.0 ml) and 4N HCl/ethyl acetate (4 ml) are added at room temperature. The reaction mixture is stirred for overnight at room temperature. The solvent is removed by evaporation to give 1.06 g of crude 2-(2-hydroxy-ethyl)-2,8-diaza-spiro[4.5]decane-1,3-dione. hydrochloride.

Workup

  1. customThe solvent is removed by evaporation

Sources & evidence

ORD record
ord-bb4585b20f094e549c033a7047b54d02
Source dataset
uspto-grants-2009_05
Patent number
US07531546B2

Reaction notes

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